Closing spread
BUF -7.5
Total
44
Model margin
+4.0est.
BUF perspective
Push chance
None
half-point line — cannot push
Availability
The injury report
The official league filing for this week — game designations first, then who missed or was limited in practice.
49ers
- OutJimmie WardCBQuadricep· DNP
- QuestionableAhmad BrooksLBGroin· Limited
- QuestionableDeForest BucknerDTFoot· Limited
- QuestionableGlenn DorseyDTKnee· Limited
- QuestionableJaquiski TarttSQuadricep· Limited
Bills
- DoubtfulMarcell DareusDTHamstring· DNP
- QuestionableAaron WilliamsSAnkle· Limited
- QuestionableCharles ClayTEKnee· Limited
- QuestionableColton SchmidtPright Quadricep· Limited
- QuestionableCorbin BryantDTAnkle· Limited
- QuestionableCordy GlennTAnkle· Limited
- QuestionableCorey WhiteCBShoulder· Limited
- QuestionableCyrus KouandjioTAnkle· DNP
- QuestionablePatrick LewisCKnee· Limited
- QuestionableZach BrownLBFoot· Limited
- DNPBrandon SpikesLBIllness
- DNPJerry HughesLBNot Injury Related
- DNPLorenzo AlexanderLBNot Injury Related
- DNPMike GillisleeRBIllness
- LimitedMarquise GoodwinWRIllness
Win probability
- Bills
- 49ers
How each play moved the game.
Matchup
Where the edges are
Season-long league percentiles for both sides, mirrored. The saturated side of a lopsided row holds the edge.
- -0.089EPA / play+0.056
- 39.6%Success rate44.9%
- -0.036EPA / dropback+0.076
- -0.169EPA / rush+0.028
- 8.0%Explosive rate10.0%
- -5.73CPOE+0.94
- 34.6%Third-down rate41.7%
- 72.1%Red-zone TD rate68.0%
- 1.59Points / drive2.08
- 2.1%Turnover rate1.1%
Bar length is league percentile, already oriented so longer is better. The saturated side of a lopsided row holds the edge; rows within ~12 points are washed as even.
The rivalry
BUF lead 4–3 since 1999
BUF have won 3 straight. Meetings average 44 points. BUF are 4-3 ATS in the series.
Possession by possession
How it unfolded
Every drive: who had the ball, how far it went, how it ended, and the score as it settled.
| Ball | Start | Plays | Yards | Result | SF–BUF |
|---|---|---|---|---|---|
| SF | Q1 15:00 | 6 | 35 | Punt | 0–0 |
| BUF | Q1 12:30 | 8 | 26 | Turnover | 0–0 |
| SF | Q1 9:36 | 7 | 23 | Field goal | 3–0 |
| BUF | Q1 5:43 | 11 | 75 | Touchdown | 3–7 |
| SF | Q1 0:14 | 4 | 75 | Touchdown | 10–7 |
| BUF | Q2 13:56 | 7 | 75 | Touchdown | 10–14 |
| SF | Q2 10:18 | 8 | 59 | Field goal | 13–14 |
| BUF | Q2 5:54 | 14 | 73 | Field goal | 13–17 |
| SF | Q2 0:21 | 0 | 0 | End of half | 13–17 |
| BUF | Q3 15:00 | 4 | 17 | Punt | 13–17 |
| SF | Q3 13:08 | 3 | 6 | Punt | 13–17 |
| BUF | Q3 12:29 | 6 | 3 | Punt | 13–17 |
| SF | Q3 9:45 | 5 | 16 | Punt | 13–17 |
| BUF | Q3 7:43 | 3 | 6 | Punt | 13–17 |
| SF | Q3 6:51 | 7 | 40 | Turnover on downs | 13–17 |
| BUF | Q3 4:29 | 4 | 60 | Touchdown | 13–24 |
| SF | Q3 2:34 | 7 | 31 | Field goal | 16–24 |
| BUF | Q4 14:48 | 8 | 75 | Touchdown | 16–31 |
| SF | Q4 10:53 | 0 | 0 | Touchdown | 16–31 |
| BUF | Q4 10:43 | 2 | 5 | Touchdown | 16–38 |
| SF | Q4 10:32 | 3 | -7 | Punt | 16–38 |
| BUF | Q4 9:05 | 7 | 63 | Touchdown | 16–45 |
| SF | Q4 5:40 | 3 | 6 | Punt | 16–45 |
| BUF | Q4 4:37 | 1 | 4 | Turnover | 16–45 |
| SF | Q4 4:28 | 7 | 17 | Turnover on downs | 16–45 |
| BUF | Q4 2:34 | 3 | 11 | End of half | 16–45 |
Box score
Individual performances
49ers
Passing
| Player | C/Att | Yds | TD | INT |
|---|---|---|---|---|
| Colin Kaepernick | 13/29 | 187 | 1 | 0 |
Rushing
| Player | Car | Yds | Avg | TD |
|---|---|---|---|---|
| Colin Kaepernick | 8 | 66 | 8.3 | 0 |
| Carlos Hyde | 14 | 52 | 3.7 | 0 |
| Mike Davis | 5 | 13 | 2.6 | 0 |
| Shaun Draughn | 1 | 2 | 2.0 | 0 |
Receiving
| Player | Rec | Tgt | Yds | TD |
|---|---|---|---|---|
| Torrey Smith | 3 | 7 | 76 | 1 |
| Quinton Patton | 4 | 7 | 52 | 0 |
| Vance McDonald | 2 | 2 | 25 | 0 |
| Rod Streater | 1 | 1 | 16 | 0 |
| Jeremy Kerley | 2 | 7 | 12 | 0 |
| Mike Davis | 1 | 3 | 6 | 0 |
| Shaun Draughn | 0 | 1 | 0 | 0 |
Bills
Passing
| Player | C/Att | Yds | TD | INT |
|---|---|---|---|---|
| Tyrod Taylor | 16/25 | 179 | 2 | 0 |
| EJ Manuel | 0/2 | 0 | 0 | 0 |
Rushing
| Player | Car | Yds | Avg | TD |
|---|---|---|---|---|
| LeSean McCoy | 19 | 140 | 7.4 | 3 |
| Tyrod Taylor | 8 | 68 | 8.5 | 0 |
| Mike Gillislee | 6 | 61 | 10.2 | 1 |
| Jonathan Williams | 5 | 21 | 4.2 | 0 |
| EJ Manuel | 3 | 11 | 3.7 | 0 |
| Reggie Bush | 2 | 6 | 3.0 | 0 |
| Robert Woods | 1 | 6 | 6.0 | 0 |
Receiving
| Player | Rec | Tgt | Yds | TD |
|---|---|---|---|---|
| Charles Clay | 5 | 7 | 52 | 0 |
| Robert Woods | 5 | 6 | 44 | 1 |
| Justin Hunter | 1 | 3 | 30 | 1 |
| Nick O'Leary | 2 | 2 | 29 | 0 |
| Marquise Goodwin | 2 | 4 | 22 | 0 |
| LeSean McCoy | 1 | 2 | 2 | 0 |
Where this game is likely to land
- Model
- Smooth (normal)
- Betting line
Probability of each final margin. Football scoring clusters — the spikes at 3 and 7 are real, and a smooth model misses them.
Positive margins favour Bills; negative favour 49ers.
Half-point at risk
2.16%
outcomes that flip if the line moves 0.5
Model home win
59.8%
Expected total
44.3est.
Model
Where the number comes from
Each component is additive, in points of expected margin.
- Team ratings (opponent-adjusted EPA)+2.52
- Home-field advantage+1.74
- Quarterback adjustment0.00
- Rest differential-0.24
- Expected margin+4.02



