2021 · Week 5 · Division

Final

49ers

San Francisco

QB Trey Lance

10·17

Cardinals

Arizona

QB Kyler Murray

State Farm Stadium · closed · grass

Closing spread

ARI -6

Total

48.5

Model margin

+2.4est.

ARI perspective

Push chance

3.1%est.

the line sits on a key number

Win probability

  • Cardinals
  • 49ers

How each play moved the game.

Cardinals wins49ers wins

Matchup

Where the edges are

Season-long league percentiles for both sides, mirrored. The saturated side of a lopsided row holds the edge.

49ersedge mapCardinals
  • +0.085EPA / play+0.079
  • 45.5%Success rate46.8%
  • +0.174EPA / dropback+0.154
  • -0.024EPA / rush-0.037
  • 10.9%Explosive rate9.4%
  • +1.73CPOE+4.19
  • 40.6%Third-down rate45.2%
  • 74.8%Red-zone TD rate62.3%
  • 2.30Points / drive2.37
  • 2.0%Turnover rate1.2%

Bar length is league percentile, already oriented so longer is better. The saturated side of a lopsided row holds the edge; rows within ~12 points are washed as even.

The rivalry

SF lead 28–22 since 1999

SF have won 2 straight. Meetings average 44.8 points. ARI are 23-26-1 ATS in the series.

Previous meetings
SeasonMatchupScoreWinner
2025 · W11SF @ ARI4122SF
2025 · W3ARI @ SF1516SF
2024 · W18SF @ ARI2447ARI
2024 · W5ARI @ SF2423ARI
2023 · W15SF @ ARI4529SF
2023 · W4ARI @ SF1635SF
2022 · W18ARI @ SF1338SF
2022 · W11SF @ ARI3810SF

Box score

Individual performances

49ers

Passing

PlayerC/AttYdsTDINT
Trey Lance15/2919201

Rushing

PlayerCarYdsAvgTD
Trey Lance16895.60
Elijah Mitchell9434.80
Deebo Samuel Sr.11313.01
Trey Sermon177.00

Cardinals

Passing

PlayerC/AttYdsTDINT
Kyler Murray22/3123910

Rushing

PlayerCarYdsAvgTD
Rondale Moore33812.70
James Conner10292.91
Chase Edmonds6152.50
Christian Kirk11111.00
Kyler Murray710.10

Receiving

PlayerRecTgtYdsTD
DeAndre Hopkins69871
Rondale Moore56590
Christian Kirk55390
Chase Edmonds34190
Maxx Williams11140
A.J. Green12130
James Conner1180

Where this game is likely to land

  • Model
  • Smooth (normal)
  • Betting line

Probability of each final margin. Football scoring clusters — the spikes at 3 and 7 are real, and a smooth model misses them.

line +64.0%2.7%7.0%7.5%3.1%4.7%3.0%

Positive margins favour Cardinals; negative favour 49ers.

Half-point at risk

3.10%

outcomes that flip if the line moves 0.5

Model home win

55.5%

Expected total

44.5est.

Model

Where the number comes from

Each component is additive, in points of expected margin.

  • Team ratings (opponent-adjusted EPA)-1.01
  • Home-field advantage+1.71
  • Quarterback adjustment+1.70
  • Rest differential0.00
  • Expected margin+2.40